The three other pyruvate kinase isoenzymes are type M1, type L and type R. The PKM-gene encodes for pyruvate kinase isoenzyme type M2 as well as pyruvate kinase isoenzyme type M1. Description The human PKM gene is 32, kb long and consists of 12 exons and 11 introns.
Both mRNAs are base pairs long and differ from another within nucleotide residues from The PKM gene is induced by hormones, mitogenic pathways and nutrients. The thyroid gland hormone triiodothyronine T3 induces PKM gene expression in rat pituitary cells and the monomeric form of the PKM protein has been identified as T3-receptor. Evidence for a role of hypoxia, and the key nutrients glucose and glutamine, in the regulation of PKM gene expression has also been reported.
The regulation of the PKM gene at the promoter level is, however, not well understood. A carbohydrate-response element ChoREwhich integrates regulation of many glycolytic genes in response to changes in glucose concentration, has not yet been precisely localized in the PKM promoter region. However, putative consensus DNA-binding elements for USF Upstream stimulating factora transcription factor which is involved in glucose-response, HIF-1alpha Hypoxia-inducible factor and the oncogenic transcription factor Myc are present within the PKM promoter region.
However, direct evidence for a role of these transcription factors in the stimulation of PKM gene expression has bot been obtained. Pseudogene No Pseudogenes. Molecular structure of the human PKM2 protein.
Description Each monomer of PKM2 consists of amino acids and can be subdivided into four domains: the N-domain aathe A-domain aa andthe B-domain aa and the C-domain aa The molecular weight of the M2-PK monomer is 58 kD. In contrast to the other PK isoenzymes which are characterized by a tetrameric quaternary structure, M2-PK occurs in a tetrameric as well as dimeric form.
The dimeric form of M2-PK is the result of intracellular contact between the A-domain of two monomers. The tetrameric form occurs by association of the interface of the C-domains of two dimers. The C-domain contains 44 amino acids of the 56 amino acid stretch aa which differs between M1 and M2-PK-isoenzymes and is responsible for the different kinetic characteristics and regulation mechanisms found for M1 and M2-PK, i. The cleft formed between the A- and B-domain is the location of the active site of the enzyme.Ewing Sarcoma 1.
Copy number: The relative copy number pipeline used varies by cell line. The remaining lines use SNP array data as explained in See By using this site, you agree to our Terms and Conditions Got it! Toggle navigation. Dependent Cell Lines. Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.
Probability of Dependency: Probabilities of dependency are calculated for each gene score in a cell line as the probability that score arises from the distribution of essential gene scores rather than nonessential gene scores. See here for details. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes. X is chosen empirically using the minimum of the distribution of gene ranks in their 90th percentile least depleting lines.
View details. Enriched Lineages. Enriched lineages have p-values View details. Top Co-dependencies. Target Tractability. RNAi Broad. RNAi Novartis.
Expression Public 20Q1. Copy Number Absolute. Copy Number Public 20Q1. Mutation Public 20Q1. Fusion 20Q1. Methylation 1kb upstream TSS 15 CpG Methylation. Proteomics P Expression Public 20Q1 Explore relationships with other data. Copy Number Absolute Explore relationships with other data. Copy Number Public 20Q1 Explore relationships with other data.
Mutation Public 20Q1 Loading table Fusion 20Q1 Loading table Methylation 1kb upstream TSS 15 Explore relationships with other data.The Gene Browser allows to navigate the human genome and investigate the relationship between PDB entries and genes. Warning You are using a web browser that we do not support. Our website will not work properly.
Please update to a newer version or download a new web browser, such as Chrome or Firefox. Dalliance goes here If the zoom level is high enough, it can show the nucleotides at the corresponding location, or a graphical encoding for each nucleotide A: green, T: red, G: yellow, C: blue. Clicking on this track shows additional information and links for more information. White boxes represent UTRs untranslated regions. Orange: protein coding regions.
The black lines connecting boxes represent introns. UCSC genome browser. View list of all current human gene IDs. View protein features Protein Feature View. UniProt: P Ensembl ENSG Omim: GenBank: M A ruler that provides location information. GRCh37 assembly.Unity gl draw texture
The blue boxes on this track indicate regions for which coordinates have been observed in PDB. This track represents the gene-structure on the genome.PKM has 9, functional associations with biological entities spanning 8 categories molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA extracted from 87 datasets.
If available, associations are ranked by standardized value. The harmonizome: a collection of processed datasets gathered to serve and mine knowledge about genes and proteins. Database Oxford. Toggle navigation. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate.Bootstrap 4 autocomplete dropdown
This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis.
Several alternatively spliced transcript variants encoding a few distinct isoforms have been reported. Klijn et al. Phosphosite Textmining Biological Term Annotations biological terms co-occuring with PKM protein in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset. This gene encodes a protein involved in glycolysis. DrugBank Drug Targets.
GO Biological Process Annotations. GO Cellular Component Annotations. GO Molecular Function Annotations. Hub Proteins Protein-Protein Interactions.
HumanCyc Pathways. KEA Substrates of Kinases. Pathway Commons Protein-Protein Interactions. Phosphosite Textmining Biological Term Annotations. PhosphoSitePlus Substrates of Kinases. PID Pathways.
Reactome Pathways. Wikipathways Pathways.Many probes fall outside of coding regions and are not displayed on the Histogram. The gene view histogram is a graphical view of mutations across PKM. These mutations are displayed at the amino acid level across the full length of the gene by default. Restrict the view to a region of the gene by dragging across the histogram to highlight the region of interest, or by using the sliders in the filters panel to the left.
Show more. This default peptide view shows a histogram of single base substitutions, colour coded by residue according to the colour scheme used in Ensembl. Under this is shown the amino acid sequence and the Pfam protein structures, followed by complex mutations and insertions and deletions. The graphical view can be switched to cDNA coordinates by selecting from the "Coordinate system" options in the "Filters" panel on the left. You can use the filters panel to select the types of data that are displayed.
After adjusting a filter, press Apply filtersor press Reset filters to revert to the original, unfiltered display. You can see more information on the help pages. This section gives an overview of PKM, along with links to any related data and resources. This section shows the drugs associated with PKM resistance mutations.
Pyruvate kinase PKM
In the tabs below you can see any other genes that have resistance mutations to the same drug sand the distribution of mutations that occur in those genes. Histograms show the percentage of mutated samples for point mutations, CNV data and gene expression data. Moving your mouse over the histograms will show additional data.
You can see additional information about the data presented here in the help pages. Note that you can also view the genome browser in a separate page. Note: in some web browsers the genome browser may display a blank content panel when switching between browser tabs or when returning to the page using the browser's Back button. If this happens please click and drag the blank content panel to reload the genome browser. This section displays a series of charts that show the distribution of different types of mutations for PKM.
The first chart in this section shows a summary of the types of mutation that have been observed in samples for this gene. The table shows the number of samples recorded as having a particular type of mutation, with the number in brackets giving the percentage of samples with that type of mutation. Note that a sample may have more than one type of mutation, so the total number of samples determined by simply summing the values in the table may not match the total number of unique samples given under the table.This gene encodes a protein involved in glycolysis.
The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones.
PKM - pyruvate kinase M1/2
This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Several alternatively spliced transcript variants encoding a few distinct isoforms have been reported.
An important paralog of this gene is PKLR. Genes Participants. Jump to section.Bhut baar aai yade song djpunjab
Antibodies Assays Proteins Inhib. This protein has been found to bind Opa pr See more Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells.
The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival PubMed, PubMed, PubMed Additional gene information for PKM Gene.
Promoters and enhancers for PKM Gene. Exists as a monomer in the absence of D-fructose 1,6-bisphosphate FBPand reversibly associates to form a homotetramer in the presence of FBP. The monomeric form binds T3. Tetramer formation induces pyruvate kinase activity. The tetrameric form has high affinity for the substrate and is associated within the glycolytic enzyme complex. Exists in a nearly inactive dimeric form in tumor cells and the dimeric form has less affinity for the substrate.See Using the Quick Search Tool for more information.
Pkm Gene Detail. Pk-2, Pk3, Pk-3, Pkm2. Strain Comparison. UniProt: P Vertebrate Homology Class 1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus. Mutations, Alleles, and Phenotypes. Phenotype Overview. Mice homozygous for a spontaneous allele exhibit prenatal lethality around the time of implanatation.
Molecular Function. Biological Process. Cellular Component. Expression Overview. GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations. Assay Results.General maths quiz questions with answers for class 10
Tissue x Stage Matrix. Allen Institute. Expression Atlas. Xenbase pkm.
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